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Drusa (Fexofenadine)

Drusa is a selective, non-sedating H1 receptor antagonist, marketed in the United States since 2000. The FDA approved an oral suspension in 2006, for the treatment of seasonal allergic rhinitis and chronic idiopathic urticaria in children. The tablet, capsule, and oral suspension are bioequivalent. Although Drusa does not use P450 CYP 3A4 it does interact with a number of drugs at P-glycoprotein and organic anion transporter polypeptides. The risk of toxicity from other drugs may increase with the administration of Drusa. Orange and grapefruit juices reduce the bioavailability of Drusa. Drusa has been shown to have an impact on inflammatory mediators, other than histamine, such as decreasing the production of LTC(4), LTD(4), LTE(4), PGE(2), and PGF(2α); inhibiting cyclo-oxygenase 2, thromboxane; limiting iNOS generation of NO; decreasing cytokine levels (ICAM-1, ELAM-1, VCAM-1, RANTES, I-TAC, MDC, TARC, MMP-2, MMP-9, tryptase); and diminishing eosinophil adherence, chemotaxis, and opsonization of particles. These effects may provide benefit to some of the inflammatory responses of an acute allergic reaction and provide a basis for future development of H1 antagonists with stronger anti-inflammatory effects. These studies also support the contention that Drusa is effective for the treatment of allergic rhinits and chronic idiopathic urticaria.

Other names for this medication:
Fexofenadine, Aerodan, Allerfex, Allerstat, Altiva, Axodin, Drusa, Feksine, Fenadex, Fenadin, Fenax, Fenixa, Fexidine, Fexo, Fexodine, Fexofast, Fexofen, Fexofenadin, Fexofenadina, Fexotabs, Histafree, Histaloc, Nefoxef, Rinolast, Telfast, Telfexo, Xergic,

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Drusa is used to relieve the allergy symptoms of seasonal allergic rhinitis (''hay fever''), including runny nose; sneezing; red, itchy, or watery eyes; or itching of the nose, throat, or roof of the mouth in adults and children 2 years of age and older. It is also used to relieve symptoms of urticaria (hives; red, itchy raised areas of the skin), including itching and rash in adults and children 6 months of age and older. Drusa is in a class of medications called antihistamines. It works by blocking the effects of histamine, a substance in the body that causes allergy symptoms.

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Characterization of calcium phosphate deposited on valve metal by anodic oxidation with polarity inversion. Our results showed that salivary and plasma levels of total antioxidant status in erosive OLP patients were lower than those in healthy subjects.

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Probiotics are viable, nonpathogenic microorganisms (bacteria or yeast) which when administered in adequate amounts, confer a health benefit on the host. The results from the two approaches are similar when the dispersivity is small.

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On the nature of the eczematogenic component of oxidized delta 3-carene. To evaluate the differences, the cases are presented and the best timing of surgery is discussed. PR toxin reacted with model neutral and basic amino acids and the formation of PR imine from PR toxin in the presence of blue cheese was demonstrated. At the atomic level the analyses include the spatial disposition of oxygen atoms around tyrosine residues, and the frequency and type of contact between carbon, nitrogen and oxygen atoms.

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Male-to-female (MTF) transgender women experience a host of psychosocial issues such as discrimination, stigmatization, and marginalization. We reviewed the results of the last 35 patients who underwent neck liposuction, simultaneous platysma plication, subdermal CO2 laser resurfacing, and/or subcutaneous musculoaponeurotic system plication at our institution.

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Poor expansion of a spiral stone basket within the ureter often results in failure to engage a ureteral calculus. Our study demonstrates that CD133 expression correlates with the differentiation of CC and indicates that CD133 is a potential indicator for differentiation and prognosis of human CC. After stenting, respiratory infection rate was greatly reduced and no further complications related to the papillomas occurred.

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Human exposure to sulfur dioxide and ozone: absence of a synergistic effect. Clinical and molecular epidemiology of human rhinovirus C in children and adults in Hong Kong reveals a possible distinct human rhinovirus C subgroup.

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That is, we look into how different life might be if it emerged in environments similar to that required for life on Earth. Adrenomedullin, a potent endogenous vasodilating and natriuretic peptide, may play an important role in the pathophysiology of chronic heart failure. However, we treated three patients who experienced palinopsia as an isolated symptom, apparently as a side effect of trazodone hydrochloride therapy for depression. The new original long linear probe was effective for creating transmural linear atrial lesions with the irrigation method, presenting the possibility of an intraoperative technique that mimics the maze procedure.

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The broadest range of inhibitory activities was expressed by Pseudoalteromonas tunicata which inhibited all target fouling organisms. However, translation of this knowledge into clinical practice has been hampered by the limitation of many in vitro and in vivo models to confirm mechanisms and to test antifibrotic agents, as well as the lack of sensitive methodologies to quantify the degree of liver fibrosis and the dynamics of fibrosis progression or reversal. We developed an original computer program that simulates upper limb reconstruction surgery using three-dimensional (3D) bone models constructed from computed tomography (CT) data. Aplastic anaemia preceding acute lymphoblastic leukaemia in an adult with isolated deletion of chromosome 9q. Development and evaluation of an aerosol generation and supplying system for inhalation experiments of manufactured nanoparticles.

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A SIMPLER GRAPH FOR USE IN DETERMINING OXYGEN SATURATION OF BLOOD BY MEANS OF SPECTROPHOTOMETRY. Broadly neutralizing antibodies against hepatitis C virus: new hope for immunization?

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Configural processing at birth: evidence for perceptual organisation. An acute short exposure of human subjects to a simulated altitude of 4,600 m fails to induce any noticeable effect on the thermal evaporative response or on the central and cutaneous temperatures. In the differential diagnosis of abdominal pain, cholelithiasis should be taken into account, even in the youngest children. Factors related to clinically probable REM sleep behavior disorder in Parkinson disease.

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Alternative oxidases (AOX1a and AOX2) can functionally substitute for plastid terminal oxidase in Arabidopsis chloroplasts. The aim of this work is to develop a cationic pullulan that can be used for gene delivery applications targeted to liver cells. The influence of pneumatization of mastoid bone on caloric nystagmus response. Differences in early evoked responses to multisensory stimuli were also detected.

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The Dominican Republic conjoined twins: ischiopagus, tetrapus, omphalophagus. Anterior transolecranon fracture dislocation of the elbow is relatively uncommon in children. Phosphoinositide 3-kinase induces the transcriptional activity of MEF2 proteins during muscle differentiation.

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A new phenyldihydronaphthalene-type lignan, vitexdoin A (1), a new phenylnaphthalene-type lignan alkaloid, vitedoamine B (2), four new phenylnaphthalene-type lignans, vitexdoins B-E (3-6), and four known lignan derivatives (7-10) were isolated from Vitex negundo seeds. Primary renal lymphoma: report of three new cases and literature review. Although these results seem to link apoptosis to muscle atrophy, the causative role of apoptosis in this process still needs to be established. Under similar reaction conditions, varying the pH of the incubation medium and adding inhibitors or activators, the histochemical and biochemical reactions are compared. The levels of the salivary amylase secretion and concentration was slow while the disease was present making difficult the nutritional recuperation in each patient.

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Apigenin possesses anti-inflammatory activity in hPDL cells and works through a novel mechanism involving the action of HO-1. Identification of chromosomal aberrations associated with disease progression and a novel 3q13.31 deletion involving LSAMP gene in osteosarcoma. Bovine serum albumin increased the hemolysis of human erythrocytes induced by dilauroylglycerophosphocholine or didecanoylglycerophosphocholine: it shortened the lag time of lysis and reduced the amount of phosphatidylcholine required for lysis.

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Determination of audiometric zero point for air and bone conductivity in extended range of high frequency Malaria control in the African Region: perceptions and viewspoints on proceedings of the Africa Leaders Malaria Alliance (ALMA).

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