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Acifar (Acyclovir)

Acifar is a prescription medication used to treat infections caused by the varicella-zoster and herpes viruses. Acifar belongs to a group of drugs called nucleoside analogues, which work by stopping the spread of herpes virus in the body. Acifar comes in a tablet, capsule, and oral suspension form, and is to be taken 2 to 5 times a day with or without food. Acifar comes in a buccal tablet that is applied as a singe dose to the upper gum region. Do not crush, chew, suck or swallow buccal tablets. This medication is additionally available in an injectable form to be given directly into a vein (IV) by a healthcare professional. Acifar also comes as an ointment and cream forms. The cream is to be applied 5 times daily for 4 days, and the ointment is applied 6 times per day for 7 days. Common side effects of Acifar tablet, capsule, suspension, and injectable include nausea and vomiting. Common side effects of Acifar buccal tablet include headache and application site pain. Common side effects of Acifar cream and ointment include dry, cracked lips and dry skin, and general skin irritation at site of application.

Other names for this medication:
Acyclovir, Abduce, Acic, Aciclobeta, Aciclomed, Aciclostad, Aciclovirum, Acifar, Acihexal, Aciklovir, Acitop, Acivir, Acivirex, Acivision, Acix, Actios, Activir, Acycloguanosine, Acyl, Acyrax, Acyvir, Aklovir, Antivir, Asiviral, Avir, Aviral, Avix, Avorax, Blistex, Cicloferon, Cicloviral, Clinovir, Clirbest, Clopes, Clovate, Clovir, Cusiviral, Cyclomed, Cyclovax, Cyclovex, Cyclovir, Danovir, Declovir, Epsin, Eurovir, Hascovir, Hernovir, Herperax, Herpesil, Herpesin, Herpex, Herpin, Herplex, Heviran, Immunovir, Lisovyr, Lovir, Lovire, Lovrak, Medovir, Menova, Ocuvir, Poviral, Ranvir, Remex, Rexan, Scanovir, Sitavig, Sophivir, Soviclor, Supraviran, Telviran, Uniplex, Vilerm, Viraban, Viralex, Viratac, Viratop, Virest, Virestat, Virex, Virless, Viroclear, Virolex, Viromed, Virosil, Virostatic, Virovir, Virucid, Viruderm, Virustat, Virux, Vivorax, Xiclovir, Xorox, Zevin, Ziverone, Zoral, Zorax, Zoraxin, Zovirax,

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Acifar buccal comes as a delayed-release buccal tablet to apply to the upper gum in the mouth. The delayed-release buccal tablet is usually applied with a dry-finger within 1 hour after cold sore symptoms (itching, redness, burning or tingling) begin, but before the cold sore appears. It is usually taken as a single (one-time) dose. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Use Acifar exactly as directed. Do not use more or less of it or use it more often than prescribed by your doctor.

Do not chew, crush, suck, or swallow the delayed-release buccal tablets.

You may eat and drink while the tablet is in place. Drink plenty of liquids, if you have a dry mouth while using the delayed-release buccal tablets.

To use buccal Acifar, follow these steps:

  1. Find the area on the upper gum above your left or right incisor teeth (the teeth just to the left and right of your two front teeth) on the side of your mouth with the cold sore.
  2. With dry hands, remove one delayed-release tablet from the container.
  3. Place the flat side of the tablet on your fingertip. Gently apply the rounded side of the tablet to the upper gum area as high as it will go on your gum above one of your incisor teeth on the side of your mouth with the cold sore. Do not apply it to the inside of the lip or cheek.
  4. Hold the tablet in place for 30 seconds.
  5. If the tablet does not stick to your gum or if it sticks to your cheek or the inside of your lip, reposition it to stick to your gum. Leave the tablet in place until it dissolves.
  6. Do not interfere with the placement of the tablet. Check to see if the tablet is still in place after eating, drinking, or rinsing your mouth.

If the delayed-release buccal tablet comes off within the first 6 hours of application, reapply the same tablet. If it still will not stick, then apply a new tablet. If you accidentally swallow the tablet within the first 6 hours after application, drink a glass of water and place a new tablet on your gum. If the tablet falls off or is swallowed 6 or more hours after application, do not apply a new tablet.

Avoid the following while you are using Acifar buccal delayed-release tablet:

  • Do not touch, or press the buccal tablet after it has been applied.
  • Do not chew gum.
  • Do not wear upper dentures.
  • Do not brush your teeth until it dissolves. If your teeth need to be cleaned while the tablet is in place, rinse the mouth gently.

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Mitochondrial gene replacement in primate offspring and embryonic stem cells. Wild-type sialyltransferases and their mutants have been applied with or without other sialoside biosynthetic enzymes for producing complex sialic acid-containing oligosaccharides and glycoconjugates. The present study was aimed to investigate the effects of rutin on UVB-induced inflammation in mouse skin in vivo.

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Therefore, urea can effect the transfer of H1 from particles with linker to particles with no linker. A case of self-induced pattern-sensitive epilepsy was observed in a 13-year-old girl.

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The expression of TRPV1 decreased in low grade and even more in high grade carcinoma when compared with normal urothelium, while TRPV4 expression was unchanged in all samples. Platelet thrombus initiation occurred more rapidly at higher wall shear rate in venules and at lower wall shear rate in arterioles. Multimeric grain-marked micelles for highly efficient photodynamic therapy and magnetic resonance imaging of tumors.

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Our findings indicate that the nature of HNO-derived modifications of C-terminal cysteines is affected by the C-terminal carboxylate. Its infusion led to reduction of diastolic pressure in the pulmonary artery from 19.0 to 16.7 mm Hg and rise of cardiac index from 2.26 to 2.4 1/min/m2 (statistically untrustworhty difference). Sixteen ECs were selected based on their popularity in the Polish, U.K. Electron microscopic and histochemical study of the localization of adenylate cylase and acetylcholinesterase in the synapses of the rat cerebral cortex and basal ganglia Circular dichroism spectroscopy was used to measure protein thermal denaturation profiles.

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Although magnetic resonance imaging (MRI) is the optimal imaging modality to define cerebral white-matter injury (WMI) in preterm survivors, the histopathological features of MRI-defined chronic lesions are poorly defined. This bidirectional relationship suggests that migraine and depression may share common causative factors, possibly genetically determined, that might control migraine chronification. Further studies are warranted to establish the optimized antiangiogenesis therapy for malignant gliomas.

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The results are discussed in relation to the high resistance to hypoxia of the foetal heart. Parieto-occipital areas were conceptualized as mediating centers for the integration of tactile and visual information, as well as for the processing of higher cortical functions. The method of statistical mechanics is used to investigate several properties of self-condensing vinyl polymerization system. Treatment persistence to antidepressant medications was poor during pregnancy in low-income, insured pregnant women. Why are we not all allergic: basic mechanisms for tolerance development.

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Physiological abnormalities are, however, more difficult to assess. Thus, a better understanding of the AAV-HSC interactions, and the availability of a vast repertoire of novel serotype and capsid mutant vectors, are likely to have significant implications in the use of AAV vectors in high-efficiency transduction of HSCs as well as in gene therapy applications involving the hematopoietic system. Reperfusion injury after pulmonary transplantation can contribute significantly to postoperative pulmonary dysfunction. Ratios of cell count before and after rinsing with culture medium and ratios of cells showing morphological signs of spreading to total cells were calculated to measure effectiveness of attachment factors.

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We set out to assess the evolutionary rate and pattern of experimentally characterized human transcription factor binding sites (TFBS) that are derived from repetitive versus non-repetitive DNA to test whether repeat-derived TFBS are in fact rapidly evolving. This article highlights the recent progress in our understanding of key interactions of influenza viruses with the type I IFN defense, which are central to viral virulence. Mesh reinforcement of pancreatic transection decreases incidence of pancreatic occlusion failure for left pancreatectomy: a single-blinded, randomized controlled trial. The first fraction contained mainly lipopolysaccharide which possessed no enterotoxic activity measured by the fluid accumulation in the ligated rabbit ileal loop as well as no activity in the skin permeability test.

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Differences in presentation characteristics of renal cell carcinoma in the last 25 years: a single center experience. Screening relatives of patients with familial chronic open angle glaucoma. These estimates include the cost of both the algorithmically based screening programme and the hospital assessment of true and false positives. On the cardiac contractile, electrophysiological and biochemical effects of endothall, a protein phosphatase inhibitor.

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The inverse primary care law in sub-Saharan Africa: a qualitative study of the views of migrant health workers. The cyclic peptide showed no effect on the E2-stimulated release of matrix metalloproteinases 2 and 9 nor on the shedding of heparin-binding EGF into the culture medium. A comprehensive health promotion approach that draws on outside technical assistance for support and capacity when needed is recommended to advance tobacco control in Niue. Chronotropic dose response of atropine in Nigerians with congestive heart failure: assessment of ethnic variation and reversibility of parasympathetic dysfunction. Restricted feeding increased mean plasma GH concentrations and the amplitude of GH pulses, but did not affect GH pulse frequency.

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