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Spironolactone
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Spironolactone

Spironolactone is used to treat high blood pressure and heart failure. Lowering high blood pressure helps prevent strokes, heart attacks, and kidney problems. It is also used to treat swelling (edema) caused by certain conditions (such as heart failure, liver disease) by removing excess fluid and improving symptoms such as breathing problems. Spironolactone is also used to treat low potassium levels and conditions in which the body is making too much of a natural chemical (aldosterone). Spironolactone is known as a "water pill" (potassium-sparing diuretic). Spironolactone has also been used to treat excessive hair growth (hirsutism) in women with polycystic ovary disease.

Other names for this medication:
Spironolactone, Aldactone, Aldactazide, Aldactazine, Aldazida, Aldazide, Aldozone, Alexan, Alizar, Carpiaton, Espirone, Espironolactona, Expal, Kespirona, Lanx, Letonal, Osiren, Osyrol, Practon, Prilactone, Spiractin, Spiresis, Spirix, Spiroctan, Spirolang, Spirolon, Spiron, Spirono, Spironolacton, Spironolactona, Spironolakton, Spironolattone, Spirotone, Verospiron, Xenalon,

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Spironolactone is used to treat certain patients with hyperaldosteronism (the body produces too much aldosterone, a naturally occurring hormone); low potassium levels; heart failure; and in patients with edema (fluid retention) caused by various conditions, including liver, or kidney disease. It is also used alone or with other medications to treat high blood pressure. Spironolactone is in a class of medications called aldosterone receptor antagonists. It causes the kidneys to eliminate unneeded water and sodium from the body into the urine but reduces the loss of potassium from the body.

High blood pressure is a common condition and when not treated, can cause damage to the brain, heart, blood vessels, kidneys and other parts of the body. Damage to these organs may cause heart disease, a heart attack, heart failure, stroke, kidney failure, loss of vision, and other problems. In addition to taking medication, making lifestyle changes will also help to control your blood pressure. These changes include eating a diet that is low in fat and salt, maintaining a healthy weight, exercising at least 30 minutes most days, not smoking, and using alcohol in moderation.

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Four different genetic tests for recombination showed that sexual exchanges must be inferred to account for the between-locus and between-chromosome marker combinations observed. Activity and characterization of a low molecular fraction present in human amniotic fluid with broad spectrum antibacterial activity.

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Moreover, analyses of the illustrative data set show that the results obtained by the two methods may differ considerably with regard to some of the substantive conclusions. The effect of graded exercise on the secretion of cortisol, testosterone, prolactin, growth hormone, thyroid stimulating hormone (TSH), luteinizing hormone and follicle stimulating hormone (FSH) is reported.

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Surgical resection for locally invasive renal cell carcinoma: Is it worthwhile? In addition, the osteoblast lineage, including osteoblast progenitors, matrix-producing osteoblasts, bone lining cells, and matrix-embedded osteocytes, produce both inhibitory and stimulatory factors that stimulate osteoclast differentiation. Paradoxically, this opportunity is often missed in the clinical practice setting due, in part, to inattention to the family history and/or lack of knowledge about breast cancer genetics. It is proposed that the therapeutical concept of pharmacological vasodilation should not be rejected in general. Thus, CD133-high cells may be resistant to TRAIL due to high expression of FLIP.

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A mixed cutaneous infection caused by Nocardia brasiliensis and Exophiala jeanselmei is reported in a liver transplant patient. Correlation between Degree of Radiologic Signs of Osteoarthritis and Functional Status in Patients with Chronic Mechanical Low Back Pain. During the deposition of the exocuticle, the apical plasma membrane of epidermal cells forms finger-like extensions and numerous invaginations. Previously we reported that activated T lymphocytes express a heparanase enzyme that degrades the heparan sulfate moiety of the proteoglycan of the extracellular matrix (ECM). If this same 35 year old man had never smoked, the probability of dying of lung cancer before age 85 was only 0.8 per cent and 5.0, 3.8, 12.5 per cent for the other smoking-related diseases.

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This peptide absorbs as cation at a longer wavelength (559 nm) than the other bilipeptides (542 - 550 nm). Chromosome deletions have several applications in the genetic analysis of complex organisms.

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The Parratt formula was used to fit the low-angle region of the reflectivity data and the resulting electron density profile (continuous base EDP or cbEDP) was then divided into a series of electron density slabs of width 1 angstroms (discrete base EDP or dbEDP), which is then easily incorporated into the Distorted Wave Born Approximation (DWBA). Polo-like kinase 1 (PLK1) has been shown to be over-expressed in a variety of tumors, becoming an attractive target for cancer management.

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Intraoperative hippocampal ECoG can predict how much hippocampus should be removed to maximize seizure-free outcome, allowing for sparing of possibly functionally important hippocampus. The Gompertz law of growth has puzzled scientists for decades: while it successfully described growth kinetics of various biological systems (e.g., tumor growth), its foundation has remained unclear. Enantioselective Ring Opening of Aza and Oxabicyclic Alkenes with Dimethylzinc. Here we show by insertion mutagenesis that the Synechocystis sp.

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They were tested for their insulin response before and after an HFD and every 3 days for the following weeks. After 17 days the control and nafenopin-treated groups were sacrificed. Motion information scalability is an important requirement for a fully scalable video codec, especially for decoding scenarios of low bit rate or small image size. Effects of Mandrax and Cannabis on the cellular function of chick embryonic neurons. Arachnoid hyperplasia in optic nerve glioma: confusion with orbital meningioma.

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Series elasticity in frog sartorius muscle subjected to stretch-shortening cycles. INVESTIGATIONS OF TETRACHLOROETHYLENE VAPORS IN 2 TYPES OF OPEN METAL CLEANING APPLIANCES However, of the diets compared, LCD had the greatest effect on glycemic variability in these patients on tube feeding. It is shown that our methods greatly improve the power for detecting association in the presence of imprinting effects.

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Compound 2 exhibited anticholinesterase properties both in vivo and in vitro. Since the types did give intuitive insight into the nature of personality as particular combinations of personality traits and also were different on variables other than those used for the classification, the scientific utility of the typological approach received support. In order to assess accurately lesions of the spinal cord in patients with cervical myelopathy we have developed a new method of examination, which is based on the Japanese Orthopaedic Association (JOA) scoring system. The underlying mechanisms are thought to be related to downregulation of the apoptotic pathway. Client-members were assessed at baseline and eight months on a measure of symptom severity and on four recovery-focused outcome measures: personal empowerment, self-efficacy, independent social integration, and hopelessness.

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The addition of bevacizumab to chemotherapy has improved progression-free survival in the first- and second-line treatment of patients with advanced-stage breast cancer. Computer prediction of biological activity spectra for low-molecular peptides and peptidomimetics Cases of adenocarcinoma had significantly higher mast cell counts than those of squamous cell carcinoma.

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Despite the low level of cytotoxicity detected for the amorphous SiO2NP investigated, these findings prompt an in-depth focus for future SiO2NP-cell/tissue investigations based on the combined analysis of more subtle signalling pathways associated with accumulation mechanisms, which is essential for establishing the bio-safety of existing and new nanomaterials. In addition, cortical models were remeshed in frequency space to compute their surface complexity. Correlation of anthropometric indices with common cardiovascular risk factors in an urban adult population of Iran: data from Zanjan Healthy Heart Study.

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A large depth of field with stereoscopic vision had a greater advantage over using an operating microscope. First-trimester Down syndrome screening may be improved by adding new markers to the current screening test and by applying different screening strategies.

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A three-phase model of the social emotional functioning in eating disorders. To assess the imaging ability and diagnostic accuracy of MPM for human bladder biopsies. A comparison of systolic time intervals measured by impedance cardiography and carotid pulse tracing. Ferulic acid potentiates neurite outgrowth in bFGF-treated PC12 cells by MAPK-dependent signaling pathway.

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Thus, the present enzymatic characterization of ThyA and ThyX from M. To evaluate bronchoalveolar lavage (BAL) findings in patients infected with human immunodeficiency virus (HIV), 39 patients seropositive for the virus but with no history of opportunistic infection were studied. FGF9 sustained delivery could potentially drive muscularization of angiogenic sprouts and help regenerate stable functional neovasculature in ischemic vascular disease patients.

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Use of human amniotic stem cells for common bile duct reconstruction: vascularized support of a free amnion graft. To analyze these movies, we have developed a software package that (i) adjusts individual scan lines and images to a common contrast and z-scale, (ii) filters specifically those scan lines where increased or insufficient force was applied, (iii) corrects for piezo-scanner drift, (iv) defines particle localization and angular orientation, and (v) performs particle tracking to analyze the lateral and rotation displacement of single molecules.

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The COWAT is a letterfluency task that is widely used in clinical neuropsychology. Hebbian learning from higher-order correlations requires crosstalk minimization. To gain more insight into the specificity of this phenomenon, the ability of SRBC to rosette with cells other thah lymphocytes was studied.

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Taken together, our data show that fiber release from incoming Ad2 requires integrins and filamentous actin. THE CHOLESTERIN FACTOR OF CICATRIZATION OF LESIONS DUE TO DIATHERMOCOAGULATION OF CERVICAL DISEASES When ET-1 was injected into Cont rats, there was a marked vasoconstriction with a sharp rise in MAP and a decline in CCP as the cavernosal arterioles constricted and limited inflow. CHF increased AngII levels in both soleus and plantaris muscle, and exercise training normalized them. Opinion dynamics on interacting networks: media competition and social influence.

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Patients with acute ischemic stroke in the setting of active cancer (especially adenocarcinoma) face a substantial short-term risk of recurrent ischemic stroke and other types of thromboembolism. In this way, we model non-linear interactions between amino acid residues.

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Deviations from healthy microbial compositions (dysbiosis) have been linked with important human diseases, including inflammation-linked disorders, such as allergies, obesity, and inflammatory bowel disease. Surgical relief of the obstruction of the biliary duct made the patient free of symptoms. Most CML cells undergo apoptosis when BCR/Abl tyrosine kinase activity is suppressed by TKIs. Hand preferences of 219 mothers and 186 fathers of autistic children were assessed using the Annett Handedness questionnaire.

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The complete sequence of the acidic subunit from Mojave toxin determined by Edman degradation and mass spectrometry. This study suggests that sensitization with SEA probably leads to enhancement of phagocytic activity of macrophages via increasing expression of Mac-1 and hence engulfment of ic3b coated schistosomal products such as ova. All of the B12 compounds detected around the location corresponding to those of methylB12, AdoB12 and sulfitoB12 in the bioautography were converted into compounds that behaved like hydroxoB12 after photolysis.

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The extension of this technique to other mammalian species, particularly livestock, might bring numerous biomedical benefits, for example, ablation of xenoreactive transplantation antigens, inactivation of genes responsible for neuropathogenic disease and precise placement of transgenes designed to produce proteins for human therapy. Institution or optimization of therapeutic measures to control cardiovascular risk factors was evaluated according to published preliminary guidelines.

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By simultaneously recording electroencephalography, physical activity, and wheel running speed, this experiment explored the theta oscillations during spontaneous running of the 12-h dark period. Both tests paralleled the clinical evolution, especially in case of disease control. Mathematical development and application to left ventricular cineangiographic measurements. An increased signaling of both growth factors and androgens are supposed to underlie benign prostate hyperplasia (BPH), one of the more common disorders of the aging male. Eight patients having coronary artery vein grafts were studied during anaesthesia, operation, perfusion and for 24 hours afterward.

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The natural transmission mechanism(s) of the simian trypanosomiases in South Asia remains an unsolved problem. Individuals who were over 65 years of age and who were able to participate in a 1 h interview were chosen for this study. Both sarcopenia and malnutrition can have a significant impact on health and functional status in older people. Separation and partial purification of two differentially inducible UDP-glucuronyltransferases from rat liver. Myeloid specific human CD33 is an inhibitory receptor with differential ITIM function in recruiting the phosphatases SHP-1 and SHP-2.

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Primary leiomyosarcoma of the seminal vesicle is exceedingly rare. These were structurally characterized and their activities for each reaction step were determined. By means of this amino acid fingerprint we were able to determine that one ADP binding site in rubredoxin reductase (AlkT) is located at the N terminus and is involved in FAD binding, while the second site is located in the middle of the sequence and is involved in the binding of NAD or NADP. A statistical analysis was then conducted to predict abdominal injury outcome using 18 covariate variables, including 4 vehicle, 4 demographic, and 10 morphomic, derived from computed tomography (CT) scans. The absolute volume and subsequent volume loss in the hippocampal remnant following surgery can influence postoperative memory change.

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Clinical evaluation of different fluid-filled systems for oesophageal manometry. Preserved autonomic heart rate modulation in chronic renal failure patients in response to hemodialysis and orthostatism.

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Local alteration in adenylate cyclase activity and stimulation response at implantation site in rabbit endometrium during early pregnancy. Here, we present the first molecular inhibitor, 4-bromoacetoxy-1-(S-glutathionyl)-acetoxy butane (4BAB), able to covalently bind to the free sulfhydryl group of Cys60 in the hydrophobic binding pocket adjacent to the enzyme active site and partially inactivate the enzyme. Four different cDNA libraries were sequenced, respectively at the beginning and at the end of drupe development. Moreover, GAK binds to the gamma- and alpha-appendage domains of the adaptor proteins AP-1 and AP-2 in vitro and phosphorylates their medium chains.

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RAW264.7 macrophages were activated with lipopolysaccharide (LPS) in the absence or presence of DiMC, which contains four methoxy groups at two aromatic rings, curcumin containing two, bis-demethoxycurcumin (BDMC) containing none, or tetrahydrocurcumin (THC) containing two but lacking conjugated double bonds in the central seven-carbon chain. The American Association of Birth Centers: history, membership, and current initiatives. Here, we report a rare case of GCT of the upper thoracic spine with soft tissue extension to the spinal canal.

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In particular we illustrate an example of a reaction-diffusion system which cannot exhibit a diffusively-driven instability on a fixed domain but is unstable in the presence of slow growth. Composite defects of the oral cavity are often the result of trauma or advanced-stage tumor extirpation. Question of the Study In this study, safety and feasibility of thoracoscopic fenestration of pleuropericardial cysts under local and general anaesthesia is evaluated.

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Bio-ethanol production from non-food parts of cassava (Manihot esculenta Crantz). Few studies have examined the influence of weight-reduction (bariatric) surgery on cardiac autonomic control. Mast cell enzymes might activate pro-metalloproteinases, thereby destabilizing atheromatous plaques. The study was undertaken in 2006-2007, in 14 pediatric practices. Saccharomyces cerevisiae DNA can be found in a number of common laboratory media and may impact the enumeration of this yeast by real-time PCR.

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We reviewed the course of 12 kidney transplant patients managed with Ho:YAG laser endoureterotomy and/or percutaneous ureteroscopic balloon dilatation for ureterovesical anastomotic strictures or ureteropelvic junction obstruction. Evidence that depression rating scales primarily measure a social undesirability response set. Letrozole combined with norethisterone acetate compared with norethisterone acetate alone in the treatment of pain symptoms caused by endometriosis. Each type of dating violence was significantly associated with other forms of dating violence (e.g., physical and psychological). Adenyl cyclase activity of the cell membrane throughout the cell cycle: ultrastructural study of the cell line BHK 21/C 13

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PHCFCs were cultured on thin disorganized reconstituted collagen substrate (RCS--five donors: average age 34.4) or on a bare polycarbonate membrane (five donors: average age 32.4 controls). The acute onset of neurologic symptoms in the immediate postoperative period should arouse clinical suspicion about the possible formation of a hematoma. The structure and composition of the silane-modified MWCNTs were characterized using scanning electron microscopy, energy dispersive spectroscopy and transmission electron microscopy. RARC and ORC cases performed from September 2007 to November 2010 were matched 1:2 by age, sex, urinary diversion, and clinical stage. Stress response of brown pelican nestlings to ectoparasite infestation.

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Estimation of bone loss biomarkers as a diagnostic tool for peri-implantitis. In the present ex vivo study we investigated the influence of fibrinogen and rFVIIa, alone or in combination, on whole blood coagulation thromboelastometry using pre- and postoperative blood samples from 18 consecutive adult patients undergoing CPB surgery. Coherent beam combination of Yb:YAG single-crystal rod amplifiers. This paper describes key aspects of this development and presents an account of how it can be explained. Next, to improve the overall antitumor immune response, we coadministered IL-12- and 4-1BBL-coexpressing oncolytic Ad with dendritic cells (DCs).

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In our region, the percentage of preschool-aged Muslim children with acute appendicitis was remarkably high. Accuracy of pharmacy and coded-diagnosis information in identifying tuberculosis in patients with rheumatoid arthritis. Structural studies of copper(II) complexes with 2-(2-aminoethyl)pyridine derived Schiff bases and application as precursors of thin organic-inorganic layers. Prader-Willi syndrome (PWS) is caused by deficiency for one or more paternally expressed imprinted transcripts within chromosome 15q11-q13, including SNURF-SNRPN and multiple small nucleolar RNAs (snoRNAs). This holds for total activity, lipoprotein lipase (LPL) activity, and hepatic triglyceride lipase (H-TGL) activity.

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Comparison of vaccination and treatment in controlling naturally occurring infectious bovine keratoconjunctivitis. Measurements of quantitative alterations of serum pseudocholinesterase levels may be useful in the treatment of patients with chronic spinal pain. Biosynthetic studies in alpha-heavy chain disease were performed on the gut tumour which was composed mainly of lymphoplasmocytic cells and on the mesenteric lymph node imox 500 mg to grams tumour composed mainly of immunoblasts.

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